Opportunity Information: Apply for PAR 21 147

The Maximizing Access to Research Careers (MARC) program (T34, Clinical Trial Not Allowed), offered through the National Institutes of Health with administration by the National Institute of General Medical Sciences (NIGMS), is designed to strengthen the pipeline of undergraduate students who go on to earn research-focused doctoral degrees in biomedical fields. The central aim is to build a larger and more diverse pool of trainees who not only complete their bachelors degrees, but also successfully transition into and finish rigorous higher degree programs such as a Ph.D. or combined M.D./Ph.D. In practical terms, the program is about giving undergraduates a structured, high-quality research training environment early enough that they develop the skills, confidence, mentoring relationships, and professional direction needed to persist into advanced biomedical research careers.

This funding opportunity (PAR-21-147) provides grant support for institutions to create or enhance undergraduate research training programs that are grounded in evidence-based training and mentoring practices and that keep pace with how quickly the biomedical research enterprise is evolving. Applicants are expected to propose a coherent training plan that blends several components rather than relying on a single experience. NIGMS anticipates programs will include formal instructional or didactic elements (for example, coursework or workshops focused on scientific thinking, responsible conduct, or other research-relevant skills), meaningful research experiences where students actively participate in research projects, strong mentoring structures that connect trainees with committed faculty and near-peer mentors, and career development activities that help students understand graduate training pathways and prepare competitive applications. The overall emphasis is on preparing participants to thrive in research-intensive, graduate-level biomedical environments.

A key feature of this opportunity is that it is limited to training programs located at research-intensive institutions. Specifically, institutions must meet a funding threshold defined in the announcement: a 3-year average of NIH Research Project Grant support at or above 7.5 million dollars in total costs. This requirement is meant to ensure that funded programs operate in environments with robust NIH-funded research activity and infrastructure, which can provide trainees with access to high-quality labs, research resources, and a strong community of active investigators.

Eligibility is restricted to domestic applicants. Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible. Within the United States and its jurisdictions, a broad set of organizations can be eligible depending on the detailed FOA requirements. The opportunity lists eligible applicant types such as public and state-controlled institutions of higher education and private institutions of higher education, as well as certain nonprofit organizations (including both 501(c)(3) and non-501(c)(3) nonprofits) and eligible tribal entities. The FOA also highlights categories of organizations that may apply, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, Indian/Native American Tribal Governments (other than federally recognized), and U.S. territories or possessions. Because institutional eligibility can hinge on specific definitions and documentation, the announcement advises applicants to consult the full FOA for complete eligibility details.

Administratively, this is a discretionary grant opportunity in the health funding category, associated with CFDA number 93.859. The original opportunity record shows a creation date of February 23, 2021, with an original closing date of May 26, 2023. The notice also states "Clinical Trial Not Allowed," meaning the supported activities are intended to be research training and career preparation rather than clinical trial execution. In short, MARC T34 supports institutions in building well-structured undergraduate training programs that combine research engagement, mentoring, and career development to help promising students progress into and complete biomedical research doctoral training.

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Maximizing Access to Research Careers (T34 - Clinical Trial Not Allowed)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859.
  • This funding opportunity was created on 2021-02-23.
  • Applicants must submit their applications by 2023-05-26. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others.
Apply for PAR 21 147

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Frequently Asked Questions (FAQs): Maximizing Access to Research Careers (MARC) Program (T34)

What is the MARC program (T34) described in this opportunity?

The Maximizing Access to Research Careers (MARC) program is an NIH-funded undergraduate research training program mechanism (T34) intended to strengthen the pipeline of undergraduate students who continue on to research-focused doctoral degrees in biomedical fields. The program emphasizes early, structured research training so students build skills, confidence, mentoring networks, and clarity about research careers that support persistence into advanced training such as a Ph.D. or combined M.D./Ph.D.

What is the main goal of this funding opportunity?

The central aim is to build a larger and more diverse pool of undergraduate trainees who complete their bachelor’s degrees and successfully transition into and finish rigorous biomedical doctoral programs. The grant supports institutions in creating or enhancing cohesive undergraduate research training programs that prepare participants for research-intensive graduate environments.

Which NIH institute administers this program?

The program is offered through the National Institutes of Health (NIH) and administered by the National Institute of General Medical Sciences (NIGMS).

What is the funding opportunity announcement (FOA) number?

The FOA number provided is PAR-21-147.

Is this opportunity focused on students or institutions?

This opportunity provides grant support for institutions to build or improve undergraduate research training programs. The intended beneficiaries are undergraduate students who participate as trainees in those institutional programs.

What kinds of program components are expected in an application?

Applicants are expected to propose a coherent training plan that blends multiple components rather than relying on a single experience. NIGMS anticipates programs will include: (1) formal instructional or didactic elements (such as coursework or workshops on scientific thinking, responsible conduct, or other research-relevant skills), (2) meaningful research experiences where students actively participate in research projects, (3) strong mentoring structures involving committed faculty and near-peer mentors, and (4) career development activities that help students understand graduate training pathways and prepare competitive applications.

What does “evidence-based training and mentoring practices” mean in this context?

Based on the description provided, the FOA expects programs to be grounded in approaches to training and mentoring that are supported by evidence and aligned with current best practices, while also keeping pace with how quickly the biomedical research enterprise evolves.

What types of student outcomes does the MARC T34 program aim to support?

The program is designed to help undergraduate trainees persist and succeed along a pathway that includes completing a bachelor’s degree, transitioning into research-focused doctoral training (such as a Ph.D. or M.D./Ph.D.), and ultimately completing that advanced degree in biomedical research fields.

Are clinical trials allowed under this opportunity?

No. The opportunity explicitly states “Clinical Trial Not Allowed,” meaning the supported activities are intended to focus on research training and career preparation rather than conducting clinical trials.

What does “Clinical Trial Not Allowed” imply for proposed activities?

It indicates that the grant-supported work should be framed around undergraduate research training, mentoring, and professional development, not the execution of clinical trials.

What type of institutions are eligible to apply?

Eligibility is limited to training programs located at research-intensive institutions, with additional eligibility restricted to domestic applicants. The opportunity lists multiple eligible applicant types (such as public or state-controlled institutions of higher education, private institutions of higher education, certain nonprofit organizations, and eligible tribal entities), but also advises applicants to consult the full FOA for complete eligibility details.

What does “research-intensive institution” mean for this FOA?

For this opportunity, “research-intensive” is defined by a funding threshold: the institution must have a 3-year average of NIH Research Project Grant support at or above $7.5 million in total costs. This requirement is intended to ensure a strong NIH-funded research environment and infrastructure for trainees.

How is the NIH funding threshold calculated?

The FOA specifies the threshold as a 3-year average of NIH Research Project Grant support at or above $7.5 million in total costs. The description provided does not include additional calculation rules beyond that statement.

Why does the FOA require a minimum NIH Research Project Grant funding level?

The requirement is meant to ensure that funded programs operate in environments with robust NIH-funded research activity and infrastructure, giving trainees access to high-quality labs, research resources, and a strong community of active investigators.

Are foreign institutions eligible to apply?

No. Eligibility is restricted to domestic applicants; foreign institutions are not eligible.

Can a U.S. organization include non-U.S. components in the application?

No. The opportunity states that non-U.S. components of U.S. organizations are not eligible.

Which categories of organizations are mentioned as eligible to apply (depending on FOA requirements)?

The opportunity notes eligible applicant types such as public and state-controlled institutions of higher education, private institutions of higher education, certain nonprofit organizations (including 501(c)(3) and non-501(c)(3) nonprofits), and eligible tribal entities. It also highlights categories that may apply, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, Indian/Native American Tribal Governments (other than federally recognized), and U.S. territories or possessions.

Does the list of eligible organization categories guarantee eligibility?

No. The description indicates that institutional eligibility can hinge on specific definitions and documentation, and it advises applicants to consult the full FOA for complete eligibility details.

What is the funding category for this grant opportunity?

It is described as a discretionary grant opportunity in the health funding category.

What is the CFDA number associated with this opportunity?

The CFDA number provided is 93.859.

What is the creation date and original closing date listed for this opportunity record?

The record shows a creation date of February 23, 2021, and an original closing date of May 26, 2023.

What is the overall emphasis of MARC T34 training programs funded under this FOA?

The emphasis is on preparing undergraduate participants to thrive in research-intensive, graduate-level biomedical environments by combining research engagement, structured mentoring, formal instruction, and career development activities geared toward successful entry into doctoral training.

What kinds of mentoring structures does the FOA anticipate?

The FOA anticipates strong mentoring structures that connect trainees with committed faculty and near-peer mentors, supporting the development of research skills and professional direction.

What kinds of career development activities are expected?

The opportunity description indicates that career development activities should help trainees understand graduate training pathways and prepare competitive applications for research-focused advanced degree programs.

Is the program intended to be a single research experience or a broader training structure?

It is intended to be a broader, coherent training plan that blends multiple components (didactic training, research participation, mentoring, and career development), rather than a single isolated experience.

What is the program trying to change or improve in the biomedical workforce pipeline?

Based on the information provided, the program aims to strengthen and diversify the undergraduate-to-doctoral pipeline by ensuring students not only gain early research training, but also persist through bachelor’s completion and successfully move into and complete biomedical doctoral programs.

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Apply for PAR 21 147

 

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