Opportunity Information: Apply for RFA AR 24 007
The HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies): Chronic Pain Program (UC2 Clinical Trial Optional) is a National Institutes of Health (NIH) funding opportunity that supports interdisciplinary, team-based research aimed at improving what is known about chronic pain in children and adolescents. It sits under NIH's broader Helping to End Addiction Long-term (HEAL) Initiative, and it is led by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) along with other participating NIH Institutes and Centers. The main emphasis is on bringing together clinical research with novel or cutting-edge technologies and rigorous measurement science so research teams can better characterize pediatric chronic pain, understand underlying mechanisms, and build a stronger foundation for therapeutic development and more effective pain management strategies.
The program is framed around the idea that pediatric chronic pain is both complex and under-served by current scientific tools and clinical approaches. Applicants are expected to propose projects that do more than describe symptoms; the goal is to integrate disciplines and methods in a way that advances understanding of both primary chronic pain conditions (where pain is the disease itself) and secondary chronic pain conditions (where pain occurs alongside another condition). By encouraging clinical research combined with advanced technologies and improved measurement, NIH is signaling that it wants projects capable of generating higher-quality, more actionable data that can translate into better interventions, better clinical decision-making, and ultimately better outcomes for young people living with persistent pain.
This opportunity uses a Cooperative Agreement mechanism (Funding Instrument Type: Cooperative Agreement), meaning NIH is likely to have substantial programmatic involvement compared with a standard research project grant. In practical terms, that usually implies closer coordination with NIH program staff, expectations around collaboration, milestone-driven progress, or participation in a broader consortium-style effort, which matches the program's "Collaborating Research Teams" structure. The activity category is listed within Health, Income Security and Social Services, and the opportunity is identified as discretionary funding.
A clinical trial is listed as optional (UC2 Clinical Trial Optional). That means applicants may propose projects that include a clinical trial component if it fits the scientific aims, but a clinical trial is not required for all applications. This flexibility is useful for teams that may be developing foundational clinical evidence, validating measurements, applying technology to real-world clinical settings, or preparing the groundwork that makes later interventional trials more feasible and informative.
The applicant pool is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include state, county, city or township governments, special district governments, and independent school districts, as well as public and state-controlled institutions of higher education and private institutions of higher education. The eligibility list also includes federally recognized Native American tribal governments, tribal organizations (including those other than federally recognized tribal governments), public housing authorities/Indian housing authorities, nonprofits with and without 501(c)(3) status (as long as they are not institutions of higher education in that nonprofit category), for-profit organizations (other than small businesses), small businesses, and other organizations. The opportunity also explicitly highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible agencies of the federal government, Indian/Native American Tribal Governments other than federally recognized, and U.S. territories or possessions.
Foreign eligibility is more restricted. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as applicant organizations. However, non-domestic components of U.S. organizations are eligible, and foreign components are allowed as defined in the NIH Grants Policy Statement. In effect, the primary applicant organization must be domestic, but certain elements of the work can include foreign components when justified and consistent with NIH policy.
Key administrative details include the Funding Opportunity Number RFA-AR-24-007 and an Original Closing Date of 2024-11-08. The opportunity was created on 2024-07-16. The award ceiling is listed as $1,300,000, indicating the maximum award amount anticipated per award under this announcement (as provided in the source data). The CFDA numbers associated with this opportunity span multiple NIH program areas (93.121, 93.213, 93.233, 93.313, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.865), reflecting the multi-institute nature of HEAL Initiative involvement and the cross-cutting relevance of chronic pain research to multiple NIH missions.
Overall, this grant opportunity is designed for research teams that can combine clinical insight, innovative tools, and strong measurement approaches to move the field of pediatric chronic pain forward. NIH is looking for projects that are collaborative by design and capable of producing results that improve scientific understanding while also laying groundwork for better therapies and management strategies for chronic pain in children and adolescents.Apply for RFA AR 24 007
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies): Chronic Pain Program (UC2 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.213, 93.233, 93.313, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.865.
- This funding opportunity was created on 2024-07-16.
- Applicants must submit their applications by 2024-11-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,300,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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